Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Summary of evidence search and selection.CENTRAL= Cochrane Central Register of Controlled Trials; CSII = continuous subcutaneous insulin infusion; HbA1c = hemoglobin A1c; MDI = multiple daily injections; rt-CGM = real-time continuous glucose monitoring;SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus.* Total number of articles may exceed the number in the corresponding box because articles could be excluded for more than 1 reason.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Mean between-group difference in the change from baseline HbA1c comparing CSII with MDI among children and adolescents with T1DM, adults with T1DM, and adults with T2DM.Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; HbA1c = hemoglobin A1c; MDI = multipledaily injections; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Pooled IRR for severe hypoglycemia comparing CSII with MDI among children and adolescents with T1DM.Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; IRR = incidence rate ratio; MDI =multiple daily injections; T1DM = type 1 diabetes mellitus.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Pooled OR for severe hypoglycemia comparing CSII with MDI among adults with T1DM.Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. CSII = continuous subcutaneous insulin infusion; MDI = multiple daily injections; OR =odds ratio; T1DM = type 1 diabetes mellitus.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Comparison of rt-CGM with SMBG and SAP use with MDI plus SMBG among patients with T1DM.Mean between-group difference in the change from baseline HbA1c among patients with T1DM comparing rt-CGM with SMBG and SAP with MDI plus SMBG (top). Pooled OR of severe hypoglycemia comparing rt-CGM withSMBG among patients with T1DM (bottom). Error bars represent 95% CIs. Shaded boxes represent individual study point estimates. Box size corresponds to weight of study. HbA1c = hemoglobin A1c; MDI = multiple dailyinjections; OR = odds ratio; rt-CGM = real-time continuous glucose monitoring; SAP = sensor-augmented pump for insulin delivery; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus.* Patients aged 15–24 y.† Patients aged 8–14 y.‡ Patients aged >25 y.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Adherence with sensor use and mean between-group difference between rt-CGM and SMBG in HbA1c changed from baseline.HbA1c = hemoglobin A1c; rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose.
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Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Between-group difference between rt-CGM and SMBG in time spent in hypoglycemic range changed from baseline among patients with T1DM.Boxes indicate individual study point estimates. The box size denotes the weight of the study, with larger boxes contributing more to the pooled estimate. The width of the horizontal lines represents the 95% CI for eachstudy. The diamond at the bottom of the figure indicates the 95% CI for the random-effects pooled estimate. Test for heterogeneity: Q = 4.24 (P = 0.52). rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus.* Patients aged >25 y.† Patients aged 8–14 y.‡ Patients aged 15–24 y.
Figure Legend:
Date of download: 6/24/2016
From: Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring forDiabetes Mellitus: A Systematic Review and Meta-analysis
Ann Intern Med. 2012;157(5):336-347. doi:10.7326/0003-4819-157-5-201209040-00508
Between-group difference between rt-CGM and SMBG in time spent in hyperglycemic range changed from baseline among patients with T1DM.Boxes indicate individual study point estimates. The box size denotes the weight of the study, with larger boxes contributing more to the pooled estimate. The width of the horizontal lines represents the 95% CI for eachstudy. The diamond at the bottom of the figure indicates the 95% CI for the random-effects pooled estimate. Test for heterogeneity: Q = 5.80 (P = 0.33). rt-CGM = real-time continuous glucose monitoring; SMBG = self-monitoring of blood glucose; T1DM = type 1 diabetes mellitus.* Patients aged >25 y.† Patients aged 8–14 y.‡ Patients aged 15–24 y.
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