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Effects of Oral Hypoglycemic Agents, Insulin And Life Style modifications On Glycemic control of Type 2 Diabetes Patients in Thailand
Presented by
Dr. Soe Sandi Tint
Background and Rationale
Diabetes Mellitus (DM) is a clinical syndrome characterized byhyperglycemia due to absolute or relative deficiency of Insulin
Type 2 Diabetes Mellitus is a Global Pandemic diseases
Chronic illness that requires continuing medical care, ongoingpatient self-management education and support, life stylemodifications and regular monitoring of their blood glucose levelwithin normal limit to prevent severe complications
Background and Rationale
Globally, about 346 million people are suffering Diabetes
Many glycemic uncontrolled Diabetes patients got complicationsafter 5 years of being diagnosed as Diabetes
In Thailand 2006, only 26.3% of participants in Thai DiabetesRegistry Project got control of HbA1c < 7%
Background and Rationale
Metformin (OHA) is the preferred initial pharmacological agent fortype 2 Diabetes
Life style modification is also one of the way to achieve the targetglycemic control level of HbA1c
Treatment with OHA, Insulin (pharmacological treatment) and Lifestyle modifications (non-pharmacological treatment) is know toreduce glycemia in patients with type 2 Diabetes
In thailand, it is still unknown that which treatment attains targetHbA1c level below 7%
Research Questions
What are the baseline characteristics (Gender, Age, BMI, Durationof Diabetes, Occupation, Health care financing) among type 2Diabetes patients in Thailand?
What are the prevalence of complications among type 2 Diabetespatients in Thailand?
What are the prevalence of Glycemic control and uncontrolled levelamong type 2 Diabetes patients in Thailand?
What is the effective treatment between pharmacological (OHA,Insulin, both OHA and Insulin) and non-pharmacological amongtype 2 Diabetes patients in Thailand?
What is the association between Glycemic level (control anduncontrolled) and baseline characteristics among type 2 Diabetespatients in Thailand?
Research Hypothesis
There is association between Glycemic level (control anduncontrolled) and baseline characteristics among type 2 Diabetespatients in Thailand
Life style modifications (non-pharmacological treatment) and OHA(pharmacological treatment) are the best effective treatment toattain the target HbA1c level (< 7%)
Objectives
To describe the baseline characteristics (Gender, Age, BMI,Duration of Diabetes, Occupation, Health care financing) amongtype 2 Diabetes patients in Thailand
To describe the prevalence of complications among type 2 Diabetespatients in Thailand?
To describe the prevalence of Glycemic control and uncontrolledlevel among type 2 Diabetes patients in Thailand?
To assess the effects of pharmacological and non-pharmacologicaltreatment on glycemic control among type 2 Diabetes patients inThailand?
Significant of the study
In Thailand, there is not much information and studies about theeffects of OHA, Insulin (pharmacological treatment) and Life stylemodifications (non-pharmacological treatment) on Glycemic controlof Type 2 Diabetes patients
Research Methodology
Study Design
Cross sectional analytical study
Study Area
Ministry of Public Health and Bangkok metropolitanAdministration Hospitals in Thailand
Study Population
Type 2 Diabetes patients aged between ---------------
Research Methodology
Inclusion Criteria
Type 2 Diabetes alone patients who are on the treatment of OHA,Insulin, both OHA and Insulin (Pharmacological treatment) and lifestyle modifications (Non-pharmacological treatment)
Sample Size
Sample = 8421 patients
Study Period
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Research Methodology
Sampling Technique
Samples were selected based on the probability proportional to sixeof the patients for each hospital
Research Methodology
Data Analysis Process
Descriptive Statistics
- Independent variables were described by using frequency and
percentage for categorical data and mean, standard deviation
were used for continuous data
- HbA1c < 7% as control group and >= 7% as uncrontrol group
were analyzed as dependent variables
Research Methodology
Data Analysis Process
Analytical statistics
- Bivariate analysis was done to measure the association between
dependent variable and independent variables
- Logistic regression was used in this analysis
- Multivariate analysis – variable having p value 0.25 or less was
included in the Multivariate model
Research Methodology
Limitation of the study
Resource and time constrain
Insufficient data and missing values in the data (secondary data)
RESULTS
Descriptive Analysis
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Descriptive Analysis
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Analytical Statistics
Analytical Statistics
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